189. Conducting Effective Negotiations When You HAVE TO Have The Deal

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166. Human Behavioral Biology: Species Evolution On A Molecular Level

09 takeaways from this lecture:

00:03:05 Recall from the previous lecture Intersexual Competition & Male/Female Hierarchies that heritability is the notion that, until proven otherwise, behaviors are genetically influenced.

On a molecular level, proteins are made up of roughly 20 amino acids coded for a different DNA sequence, and there are roughly 60 different ways of coding for amino acids. These roughly 20 amino acids are structurally responsible for holding your cell shapes together, forming messengers, hormones, neuro-transmitters, enzymes… Proteins are what get your cells to do what they are supposed to do.

One of the most interesting things that proteins do is act as enzymes which speed up the process of putting together and pulling apart molecules.

If you know the sequence of DNA, then you’ll know the sequence of RNA, the amino acid sequence, the resulting protein that is made as well as the shape and function of the protein. This tenet has since been disproved.

The central tenet in molecular biology of how life and information flows, as proposed by British molecular biologist Francis Crick was DNA>RNA>Protein; that DNA determines everything. This tenet has also since been disproved:

  • Viruses are foreign DNA which hijack another DNA and force it to do what the virus wants it to, thus changes the RNA and the proteins.
  • There is also a class of enzymes which can attack RNA and turn it back into DNA and then hijack it for it’s own objectives.

00:17:10 Micro-mutations are when one letter in a DNA sequence is accidentally miscopied or changed by radiation or some other chemical compound. Broadly, one of three mutations occurs:

  1. A point mutation is when one letter in the DNA sequence is changed into another letter.
  2. A deletion is when one of the letters in the DNA sequence gets lost.
  3. An insertion is when one of the letters in the DNA sequence gets doubled.

00:27:03 In modern times, 12 years old is the Westernized average time little girls start puberty and begin menstrating. Testicular Feminization Syndrome is a condition where genetically the human is a male complete with testes which make testosterone, but the testes never descended, and so is mistaken for a female.

All of these protein and receptor mututations effect humans evolutionarily in slow, predictable and incremental changes; changes we can identify and predict.

00:40:51 FOXP2 is an example of a genetic protein mutation that happened to humans, and is what gave humans the ability to develop speech and language. Versions of FOXP2 occur all throughout the animal kingdom.


You share 98% of your DNA with chimpanzees, yet on average only 50% of your DNA with your full siblings. To simplify, genes specify traits: kidneys, bones, antlers, etc. So right from the start you share genetic similarities with other species which also have kidneys, bones, pelvises designed to walk upright, etc. Why you have less genetic similarity with your full sibling versus with a chimpanzee comes down to coding not for the different genes, but for the different ‘types’ of genes. This is a different world of variance.

00:52:31 In the 1980s Steven Jay Guld and Niles Eldredge came up with the theory of punctuated equalibrium: that evolution isn’t being driven by small gradual changes, but rather long periods of stasis where nothing changes followed by short periods of rapid change, and then back to stasis.

The logic behind punctuated equalibrium was due mainly because Guld, a Marxist, wasn’t a biologist, but rather a paleontologist who studied fossils and traced the evolutionary lineage of change in a species through time. In the world of paleontology, you don’t have clear logical steps showing the evolution of a species as viewed from their fossils, but rather gaps in time which can neither be explained nor tracked. And as more and more data are discovered about the species, you see great similarities over time, and then gaps in the evolution where things had changed drastically over a short period.


This theory flies in the face of the idea that genetics are passed down through competition and that the strongest survive. Not surprisingly, those scientists supporting survival of the fittest weren’t happy with Guld and his punctuated equalibrium, and they attacked his theory in several sound ways:

  1. Paleontology and a evolutionary biology come from completely different universes and measure time through different orders of magnitude.
  2. Paleongology is only concerned with the fossils and morphology of organisms, not the smaller genetic modifications such as brain activity and development, behavior, and the number of chambers in the animal’s heart, etc.

01:07:10 Nobel Prize winning biologist David Baltimore found that one gene can have its protons and exons combine in many different ways. This finding was also ill-received by the scientific community which held that one gene only specifies one single protein with no variation.

A shocking 95% of your DNA is junk DNA, or noncoding DNA. This noncoding DNA acts as the instruction manual for the coding DNA

01:25:14 If then clauses in the molecular genetic world: IF you get a signal that there is low glucose in the cell, THEN you begin to make proteins related to glucose uptake. IF you smell your child, THEN you’ll experience a particular reaction.

01:29:16 Are genetics fixed or malleable based on the environment? Mothering style, such as how often a mother wakes her baby, can cause permanent changes to genes related to stress hormones, dictating how readily some genes will be turned on or off for the rest of your life.

Epigenetics is the study of “variations that are caused by external or environmental factors that switch genes on and off and affect how cellsread genes instead of being caused by changes in the DNA sequence.” The researcher Steve Sumi who studies primate social behavior found that by simply changing the style of mothering that a baby monkey receives, and you change the confirmational access state of +4,000 different genes.

Fertilization is all about genetics; development is all about ways in which the environment shapes behavior.

158. The Complicated Relationship Between Digital & Psychological Development

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157. User Interface Design: Psychological Bases For UI Design Rules

11 takeaways from this video:

[EDITOR’S NOTE: The full powerpoint presentation of this lecture is available for free download here.]

00:02:30 From Ben Schneiderman’s 1987 book Designing The User Interface to Neilsen & Molich’s 1993 website and software evaluation checklist to Stone et al in 2005…


…human-computer ‘user-interface design guidelines’ have been created and collected to provide a universal reference point for website and software creators and coders.

The intentional reason of overlap and commonalities between the above three ‘guidelines’ is that they are based on human psychology – based on how people think, reason, learn and make decisions. Despite that, the problem is that they tend to be quite vague and loosely interpreted, meaning there is no absolute and objective recipe for creating the perfect user experience.

In the early days, most of the user experience designers had degrees in cognitive psychology. Nowadays this isn’t true, and coders come from a variety of diverse backgrounds and disciplines from graphic to print design to technical writing, etc. and have received no formal training or experience in cognitive psychology.

When Stone et al’s first rule is “Visibility: First step to goal should be clear,” what EXACTLY is that supposed to mean, objectively and actionably? Further, when two rules from different guidelines appear to contradict each other, which rule takes preference?

This explains why when modern user experience experts are asked to explain usability guidelines to their clients, they have no idea why the rule is the rule, and because these rules can be vague and loosely interpreted, have no way of justifying why their chosen design meets these useability guidelines.

This is why I (Jeff Johnson) wrote the Designing With The Mind In Mind: Simple Guide to Understanding User Interface Designe Guidelines, now on it’s 2nd Edition

00:09:38 Some basic tenants of human behavior with regard to perception and cognition are:

  1. Humans perceive what they expect
  2. Human vision is optimized to see structure
  3. Humans seek and use visual structure
  4. Reading is unnatural
  5. Human’s ability to see color is limited
  6. Human’s peripheral vision is poor
  7. Humans have limited attention span and imperfect memory
  8. Limitations on attention shape our thought & action
  9. Humans learn from experience and performing learned actions are easy, while problem-solving & calculations are difficult
  10. Many factors affect learning
  11. Humans have real-time requirements

1. Humans perceive what they expect

00:10:24 Human perception is biased by their experience (the past), context (the present), and their goals (the future).

If you’ve never seen this photo by RC James before, then there’s a great chance you won’t spot the dog sniffing the ground. But if you have already seen and been explained what this photo is, then from now on you’ll immediately spot the dog; even if you’ve forgotten you’ve seen the photo.

00:13:33 When browsing your website and using your software or application, humans don’t actually pay attention to the screen, AT ALL! They’re clicking on things based on memory position. Therefore your website needs to be consistent with its button positioning and content layout itself, but you also need to remember that your user will have visited 1,000s of other websites and pages before arriving on yours, and so will approach your site like they have approached all others before yours.

And since humans are navigating your web site with an end goal in mind, anything considered superfluous or irrelevant to their goal is usually disguarded or overlooked.

[EDITOR’S NOTE: A dark pattern is “a user interface that has been carefully crafted to trick users into doing things” they don’t intentionally want to do. One such dark pattern is a disguised ad where advertisements are made to resemble content, photos, or even navigation menu bars in order to trick users into clicking on them.]

Some users are “Search people,” immediately typing keywords into your website’s search box, while others quickly scan your site for the closest keyword of what they’re looking for.

Therefore when conducting usability tests, if consumers can’t find what they’re looking for, it’s your fault for not knowing enough about the user’s past experience and current perception to know how to organize your site to cater to and persuade them.

[EDITOR’S NOTE: Recall in my interview with Product Designer Timoni West that if visitors land on your homepage and are confused about what the product is or why they should use it then your UX designer has failed. And honestly, there are TONS of startups that fail to tell you what they do. When that happens, it’s generally because the company itself doesn’t know how to articulate their product vision.

Recall also from my interview with Art Director Julien Chesné that advertising is made by brands for consumers; therefore consumers arguably do not have misconceptions. If consumers think your advertisement is bad, is deceptive, or is doing more harm than good, they are right. So in that respect consumers don’t have misconceptions, they have opinions based on their experiences and prejudgments, and it is up to you to either conform to those preconceived opinions or work to change them.

For more on how to conduct consumer testing, read my interview with Brand Listener Peter Spear. For a step-by-step user interface workshop model, watch the lecture by Janne Jul Jensen. ]

2. Human’s vision is optimized to see structure

00:20:25 Gestalt principles developed in the 1930s-40s identified what modern psychologists define as ‘descriptions’ to human visual perception and are great for designers when optimizing their web site, application and software.

00:21:51 In Gestalt theory:

  • Closure – the human brain is hardwired to see whole objects rather than fragments of objects, and
  • Symmetry – the brain is hardwired to see simple figures and shapes rather than complex ones

…in particular are interesting because your brain is making sense of things which aren’t actually there.

3. Humans seek & use visual structure

00:29:15 Structured information is easier to perceive and sort through than the same information unstructured. Structure your information rather than putting it into sentence form, and your users will more quickly and easily understand and remember it.


Creating a visual hierarchy of information with headers, subheaders and bullet points also helps users skim your content to reach their goal more quickly.

Users aren’t spending time reading all that text you spent so much time and care writing; they only want the information they came to your page for.

Human color vision is limited.

00:35:57 Human vision is optimized to see contrasts – edges & changes – and not absolute levels. As such two identical colors can actually appear to be different based on the colors surrounding it.

The human eye has difficulty distinguishing between pale colors, small color patches versus larger surface objects, and objects that are far apart versus being close together. This is especially true if eye movement between the objects because then memory is implicated.

Therefore when designing your website, don’t put similar colors too close together (for example hyperlinked text and non-hyperlinked text, and visited links versus non-visited links) because users won’t be able to easily distinguish them.

Colors will vary slightly to significantly according to display, browser, device being used, the angle at which user is viewing device, the lighting around and reflected onto the device, the population of users who have color-blindness, etc.

Therefore combine color with other cues such as images, bold or italics, and/or words and numbers.

4. Human Peripheral vision is poor

00:50:48 When using fill-in forms such as ‘contact us’ or ‘user login,’ put any error messages directly next to the location of the error rather than off to the side and distanced from where the error occurred, otherwise users risk overlooking the error message and assuming your website or software is broken or bugged.

By staring directly as the dot in the center of each image below, you can see an example of the density of your eye’s peripheral vision.

Therefore when designing your website:

  • Anticipate how users will scan/view your page and place important messages along the pathway your user’s eye will take and pause to focus on
  • Place error messages near the location of the error
  • Use a bright color such as red for error messages, or a color which completely contrasts your site’s prominent colors
  • Include an error symbol with the color-coded error message
  • Consider using popup boxes, audio beeps or screen flashes to highlight errors. But don’t do this continuously otherwise users may dismiss your error message as an annoying advertisement.

01:10:42 With portrait versus landscape design layouts, people are used to scrolling vertically, so understand that if you create a horizontally scrolling site, know that you are going against everything internet users have been primed to expect in user design. If you put information off to the left or right, you risk that content not being seen by your user.

01:12:10 Conventional colors for hyperlink text (link: #551A8 and visited: #0000EE as of HTML5). Unless you have a very specific reason for departing from conventional usage (such as for branding purposes, which is commonplace on websites today), it’s wise to take advantage of your user’s previously primed identification of url link colors. But what’s important is that when users arrive on your website they can immediately understand what they are there for, what you want them to do, and how they can navigate your site.

Go against conventional wisdom too much, and users won’t understand how to navigate your site.

155. Negotiation: Common Mistakes, Underhanded Techniques & How to Improve

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